Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells
نویسندگان
چکیده
منابع مشابه
Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts.
Khat chewing is widely practiced in Eastern Africa and the Middle East. Khat is genotoxic to cells within the oral mucosa, and several studies have suggested an association between khat use and oral lesions like hyperkeratosis and oral cancer. This study investigated the mechanism of khat-induced cytotoxicity using primary normal human oral keratinocytes (NOK) and fibroblasts (NOF). Khat induce...
متن کاملAssessment of khat (Catha edulis Forsk) 1. Substance Identification
F. WHO Review History: The WHO Expert Committee on Drug Dependence (ECDD) and other UN bodies reviewed khat at earlier occasions. The Advisory Committee on the Traffic in Opium and Other Dangerous Drugs of the League of Nations discussed on the subject in 1933, but no action was taken. On request of the Commission on Narcotics Drugs (CND), the Expert Committee on Addiction-Producing Drugs (as t...
متن کاملSevere rhabdomyolysis associated with catha edulis(khat) use
Severe rhabdomyolysis is a rare complication of exposure to the recreational drug khat. Adverse reactions to khat that have been reported in the literature include myocardial infarction and reversible vasoconstriction syndrome. The active ingredient, cathinone, is a naturally occurring beta-ketone amphetamine that may be responsible for this severe catecholaminergic response. Here we report a c...
متن کاملCatha Edulis (khat), a Sex Depressant, Euphoriant in History
This article traces the history of the Khat which is an intoxicant and also a sexual depressant. The author establishes that its origion is Abyssinia and it is brought to Arabia where it is commonly used even by Muslims. If Khat is consumed in excess it may impair the health but moderate quantity is beneficial.
متن کاملCatha edulis Forsk. (Khat): Evaluation of its Antidepressant-like Activity
BACKGROUND Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND ME...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2004
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6602197